Keywords
Dark Chocolate
Modulation
Nitric Oxide
Pandemic
How to Cite
Abstract
Coronavirus 19 is a deadly disease that can kill thousands of people worldwide. However, not many researchers know that NO content can kill the COVID-19 virus. This research method is study design used retrospective methods, prospective and a systematic review. Search for reference sources began on March 10th - June 1st, 2021, using several online databases: 1) Pubmed, 2) Science Direct, 3) Google Scholar. Keywords used in the search term: COVID-19, Novel Coronavirus, SARS-CoV, Nitric Oxide, Dark Chocolate, Macrophages and included in journals accredited. This study looked for a list of references from the study, including 103 studies taken through the search. There are 63 articles in cleaning, and eight articles are included in the discussion. This review shows that COVID-19 can be attenuated and killed by the NO content produced by macrophages and supplied with NO content modulated by dark chocolate. Modulating NO-rich foods such as dark chocolate can effectively kill COVID-19. NO can also cure several diseases such as high blood pressure, diabetes, cardiovascular disease, and some respiratory infections.
References
Liu K, Fang YY, Deng Y, Liu W, Wang MF, Ma JP, et al. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin Med J (Engl). 2020;133(9):1025–31.
Hanoatubun S. Dampak Covid-19 Terhadap Perekonomian di Indonesia. J Educ Psycology Couns [Internet]. 2020;2(2):146–53. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019?gclid=EAIaIQobChMI2Zutwsf46QIVTQ4rCh3DjQG4EAAYASAAEgKnSPD_BwE
Antonio Guterres. Covid-19 Pandemic Worsens the Global Food System. Washington DC: United Nations Publication; 2020.
Lotfi M, Hamblin MR, Rezaei N. COVID-19: Transmission, Prevention, and Potential Therapeutic Opportunities. Clin Chim Acta. 2020;508(May):254–66.
World Health Organization. Coronavirus Diseases -19 [Internet]. W.H.O Publication. 2020 [cited 2020 Jun 11]. Available from: https://www.who.int/indonesia/news/novel-coronavirus
Yang AP, ping Liu J, qiang Tao W, ming Li H. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol. 2020;84(April):106504.
Vardavas CI, Nikitara K. COVID-19 and smoking: A systematic review of the evidence. Tob Induc Dis. 2020;18(March):1–4.
Kementrian Kesehatan. Home » Info Infeksi Emerging Kementerian Kesehatan RI [Internet]. Kemenkes. Jakarta Pusat: Direktorat Jenderal Pencegahan dan Pengendalian Penyakit; 2020. Available from: https://infeksiemerging.kemkes.go.id/
World Health Organization. Coronavirus Disease 2019 [Internet]. Vol. 14, A & A Practice. New York City: World Health Organization Publication; 2020. p. e01218. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019?gclid=EAIaIQobChMI2Zutwsf46QIVTQ4rCh3DjQG4EAAYASAAEgKnSPD_BwE
Lei C, Su B, Dong H, Bellavia A, Fenza R Di, Fakhr BS, et al. Protocol of a randomized controlled trial testing inhaled Nitric Oxide in mechanically ventilated patients with severe acute respiratory syndrome in COVID-19 (SARS-CoV-2). medRxiv. 2020;9(3):1–14.
A. C, A. B, L. ZDV, A. T, F. L, M. G, et al. Neutrophil-to-lymphocyte ratio and clinical outcome in COVID-19: a report from the Italian front line. Int J Antimicrob Agents. 2020;(15892):106017.
Ciccullo A, Borghetti A, Zileri Dal Verme L, Tosoni A, Lombardi F, Garcovich M, et al. Neutrophil-to-lymphocyte ratio and clinical outcome in COVID-19: a report from the Italian front line. Int J Antimicrob Agents. 2020;18(56):1–3.
Liu Y, Du X, Chen J, Jin Y, Peng L, Wang HHX, et al. Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19. J Infect. 2020;81(1):e6--e12.
Hu B, Ge X, Wang LF, Shi Z. Bat origin of human coronaviruses Coronaviruses: Emerging and re-emerging pathogens in humans and animals Susanna Lau Positive-strand RNA viruses. Virol J. 2015;12(1):1–10.
Fan Y, Zhao K, Shi ZL, Zhou P. Bat coronaviruses in China. Vol. 11, Journal Viruses. 2019. p. 27–32.
Keyaerts E, Vijgen L, Chen L, Maes P, Hedenstierna G, Van Ranst M. Inhibition of SARS-coronavirus infection in vitro by S-nitroso-N- acetylpenicillamine, a nitric oxide donor compound. Int J Infect Dis. 2004;8(4):223–6.
Nagy G, Clark JM, Buzas E, Gorman C, Pasztoi M, Koncz A, et al. Nitric oxide production of T lymphocytes is increased in rheumatoid arthritis. Immunol Lett. 2008;118(1):55–8.
Wang X, Gray Z, Willette-Brown J, Zhu F, Shi G, Jiang Q, et al. Sustained Nitric Oxide Production in Macrophages Requires the Arginine Transporter CAT2. Cell Death Discov [Internet]. 2018;276(1):15881–5. Available from: http://dx.doi.org/10.1038/s41420-018-0046-5
Palmieri EM, Gonzalez-Cotto M, Baseler WA, Davies LC, Ghesquière B, Maio N, et al. Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase. Nat Commun [Internet]. 2020;11(1):11–22. Available from: http://dx.doi.org/10.1038/s41467-020-14433-7
Prado CM, Martins MA, Tibério IFLC. Nitric Oxide in Asthma Physiopathology. ISRN Allergy. 2011;2011(4):1–13.
Åkerström S, Mousavi-Jazi M, Klingström J, Leijon M, Lundkvist Å, Mirazimi A. Nitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus. J Virol. 2005;79(3):1966–9.
Noya ABI. Memahami Fungsi Neutrofil dalam Sistem Imunitas Tubuh. Aladokter. 2021. p. 3–5.
Wang X. Erratum: Tanshinone II a attenuates TNF-α-induced expression of VCAM-1 and ICAM-1 in endothelial progenitor cells by blocking activation of NF-κB (Cellular Physiology and Biochemistry (2016) 40 (195-206)) DOI: 10.1159/000452537). Vol. 41, Cellular Physiology and Biochemistry. 2017. p. 2132.
Nishikawa Y, Kawase O, Vielemeyer O, Suzuki H, Joiner KA, Xuan X, et al. Toxoplasma gondii infection induces apoptosis in noninfected macrophages: Role of nitric oxide and other soluble factors. Parasite Immunol. 2007;29(7):375–85.
Kahramanca Ş, Özgehan G, Şeker D, Ismail Gökce E, Şeker G, Tunç G, et al. Neutrophil to lymphocyte ratio as a predictor of acute appendicitis. Ulus Travma ve Acil Cerrahi Derg. 2014;20(1):19–22.
Proctor MJ, Morrison DS, Talwar D, Balmer SM, Fletcher CD, O’reilly DSJ, et al. A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. Eur J Cancer. 2011;47(17):2633–41.
Sudarma V, Sukmaniah S, Siregar P. Effect of dark chocolate on nitric oxide serum levels and blood pressure in prehypertension subjects. Acta Med Indones. 2011;43(4):224–8.
Ayoobi N, Jafarirad S, Haghighizadeh MH, Jahanshahi A. Protective effect of dark chocolate on cardiovascular disease factors and body composition in type 2 diabetes: A parallel, randomized, clinical trial. Iran Red Crescent Med J. 2017;19(8).
Magrone T, Russo MA, Jirillo E. Cocoa and dark chocolate polyphenols: From biology to clinical applications. Front Immunol J. 2017;8(JUN):1–13.
Tualeka AR, Rahmawati P, Ahsan, Russeng SS, Sukarmin, Wahyu A. Prediction of The Needs for Benzene Detox with Foods Intake Containing CYP2El Enzyme, Sulfation, and Glutathione at Gas Stations Pancoranmas Depok, Indonesia. Indian J Forensic Med Toxicol. 2020;14(1):118–23.
Sakizadeh M. Spatiotemporal variations and characterization of the chronic cancer risk associated with benzene exposure. Ecotoxicol Environ Saf [Internet]. 2019;182(April):109387. Available from: https://doi.org/10.1016/j.ecoenv.2019.109387
Keizman D, Ish-Shalom M, Huang P, Eisenberger MA, Pili R, Hammers H, et al. The association of pre-treatment neutrophil to lymphocyte ratio with response rate, progression free survival and overall survival of patients treated with sunitinib for metastatic renal cell carcinoma. Eur J Cancer. 2012;48(2):202–8.
Sharaiha RZ, Halazun KJ, Mirza F, Port JL, Lee PC, Neugut AI, et al. Elevated preoperative neutrophil: Lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer. Ann Surg Oncol. 2011;18(12):3362–9.
Darwish I, Miller C, Kain KC, Liles WC. Inhaled nitric oxide therapy fails to improve outcome in experimental severe influenza. Int J Med Sci. 2012;9(2):157–62.
MARRIOTT HM, ALI F, READ RC, MITCHELL TIMJ, WHYTE MKB, DOCKRELL DH. Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection. FASEB J. 2004;18(10):1126–8.
Singh AK, Awasthi D, Dubey M, Nagarkoti S, Kumar A, Chandra T, et al. High oxidative stress adversely affects NF$κ$B mediated induction of inducible nitric oxide synthase in human neutrophils: Implications in chronic myeloid leukemia. Nitric Oxide - Biol Chem. 2016;58(6):28–41.
McDonagh STJ, Wylie LJ, Webster JMA, Vanhatalo A, Jones AM. Influence of dietary nitrate food forms on nitrate metabolism and blood pressure in healthy normotensive adults. Nitric Oxide - Biol Chem. 2018;72(6):66–74.
Karaman U, Çelik T, Kiran TR, Colak C, Daldal NU. Malondialdehyde, glutathione, and nitric oxide levels in Toxoplasma gondii seropositive patients. Korean J Parasitol. 2008;46(4):293–5.
Bae S, Pan XC, Kim SY, Park K, Kim YH, Kim H, et al. Exposures to particulate matter and polycyclic aromatic hydrocarbons and oxidative stress in schoolchildren. Environ Health Perspect. 2010;118(4):579–83.
Coskun O, Oter S, Korkmaz A, Armutcu F, Kanter M. The oxidative and morphological effects of high concentration chronic toluene exposure on rat sciatic nerves. Neurochem Res. 2005;30(1):33–8.
Ren KX. Effects of different intensity walking on serum nitric oxide for the elderly men. Adv Mater Res. 2013;641(1):748–51.
Innes AJ, Kennedy G, McLaren M, Bancroft AJ, Belch JJF. Dark chocolate inhibits platelet aggregation on the health of volunteers. Platelets J. 2003;(5)2(2):285–99.
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