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Women and children are at risk of suffering iron deficiency anemia. The scoping reviews were aimed to examine experimental research articles that were published last than 10 years ago or from 2008. The searching articles results through 11 electronic search engines (Medline, CINAHL, PubMed, etc.) found 668 articles. After the screening process based on the specified inclusion criteria, 51 articles will be examined. The result of articles review that we had done showed 35 articles had positive impact after they were given an intervention with fe fortification in various types of food for all subjects. However, there were still 16 articles that showed no significant changes after being given an intervention. This review of the studies still required statistical analysis of the data found to provide a better results


World Health Organization. Iron Deficiency Anaemia: Assessment, Prevention and Control, A guide for program managers. Who Guidel. 2001;1–114.

Ejigu BA, Wencheko E, Berhane K. Spatial pattern and determinants of anaemia in Ethiopia. PLoS One. 2018;13(5):1–17.

Nguyen PH, Nguyen H, Gonzalez-Casanova I, Copeland E, Strizich G, Lowe A, et al. Micronutrient intakes among women of reproductive age in Vietnam. PLoS One. 2014;9(2).

Lover AA, Hartman M, Chia KS, Heymann DL. Demographic and spatial predictors of anemia in women of reproductive age in Timor-Leste: Implications for health program prioritization. PLoS One. 2014;9(3).

RISKESDAS. Penyakit yang ditularkan melalui udara. Jakarta Badan Penelit dan Pengemb Kesehat Dep Kesehat Republik Indones. 2013;(Penyakit Menular):103.

Prentice AM, Ward KA, Goldberg GR, Jarjou LM, Moore SE, Fulford AJ, et al. Critical windows for nutritional interventions against stunting. Am J Clin Nutr. 2013;97(5):911–8.

Sivagurunathan C, Umadevi R, Rama R, Gopalakrishnan S. Adolescent health: Present status and its related programmes in India. Are we in the right direction? J Clin Diagnostic Res. 2015;9(3):LE01–6.

Thankachan P, Selvam S, Surendran D, Chellan S, Pauline M, Abrams SA, et al. Efficacy of a multi micronutrient-fortified drink in improving iron and micronutrient status among schoolchildren with low iron stores in India: A randomised, double-masked placebo-controlled trial. Eur J Clin Nutr [Internet]. 2013;67(1):36–41. Available from:

World Health Organization. the Global Prevalence of Anaemia in 2011. WHO Rep. 2011;48.

Allen L, Benoist B De, Dary O, Hurrell R. WHO and FAO of the United Nations. Guidelines on food fortification with micronutrients. WHO Press. 2006. ISBN 92 4 159401 2.

Das JK, Salam RA, Kumar R, Bhutta ZA. Micronutrient fortification of food and its impact on woman and child health : a systematic review. Syst Rev. 2013;2(1):1.

Serdula M, Maberly GF, Parvanta I, Editors A, Jennings N, Perrine CG, et al. Flour fortification with iron, folic acid, vitamin B 12 , vitamin A, and zinc: Proceedings of the Second Technical Workshop on Wheat Flour Fortification.

Engle-Stone R, Nankap M, Ndjebayi AO, Allen LH, Shahab-Ferdows S, Hampel D, et al. Iron, Zinc, Folate, and Vitamin B-12 Status Increased among Women and Children in Yaoundé and Douala, Cameroon, 1 Year after Introducing Fortified Wheat Flour. J Nutr. 2017;147(7):1426–36.

Gera T, Pal H, Sachdev S, Nestel P. Effect of combining multiple micronutrients with iron supplementation on Hb response in children : systematic review of randomized controlled trials. 2008;12(6):756–73.

Sheng HUOJ, Yong YINJ, Jing SUN, Jian H, Xin LUZ. Effect of NaFeEDTA-Fortified Soy Sauce on Anemia Prevalence in China : A Systematic Review and. Biomed Environ Sci [Internet]. 2015;28(11):788–98. Available from:

Eichler K, Wieser S, Rüthemann I, Brügger U. Effects of micronutrient fortified milk and cereal food for infants and children : a systematic review. 2012;

Athe R, Rao MVV, Nair KM. Review Article Impact of iron-fortified foods on Hb concentration in children ( , 10 years ): a systematic review and meta-analysis of randomized controlled trials. 2013;17(3):579–86.

Szarfarc SC. Anaemia in pregnant women before and after the mandatory fortification of wheat and corn flours with iron. 2012;15(10):1802–9.

Varea A, Malpeli A, Disalvo L. Evaluation of the Impact of a Food Program on the Micronutrient Nutritional Status of Argentinean Lactating Mothers. 2012;103–8.

Ralf Biebinger, Michael B. Zimmermann, Saud N. Al-Hooti NA-H. Efficacy of wheat-based biscuit fortified with microcapsules containing ferrous sulfate and potassium iodate or a new hydrogen-reduced elemental iron: a Randomised, double-blind, controlled trial in Kuwaiti women.

Taljaard C, Covic NM, Graan AE Van, Kruger HS, Smuts CM, Baumgartner J, et al. Effects of a multi-micronutrient-fortified beverage , with and without sugar , on growth and cognition in South African schoolchildren : a randomised , double-blind , controlled intervention. 2013;2271–84.

Kounnavong S, Sunahara T, Mascie-taylor CGN, Hashizume M. Effect of daily versus weekly home fortification with multiple micronutrient powder on haemoglobin concentration of young children in a rural area , Lao People ’ s Democratic Republic : a randomised trial. Nutr J [Internet]. 2011;10(1):129. Available from:

Santos S, Barros JD, Gigante DP, Victora CG. Flour fortification with iron has no impact on anaemia in urban Brazilian children. 2012;15(10):1796–801.

Zimmermann MB, Biebinger R, Egli I, Zeder C, Hurrell RF. Iron deficiency up-regulates iron absorption from ferrous sulphate but not ferric pyrophosphate and consequently food fortification with ferrous sulphate has relatively greater efficacy in iron-deficient individuals British Journal of Nutrition. 2011;1245–50.

Vinodkumar M, Rajagopalan S. Multiple micronutrient fortification of salt. 2009;437–45.

Samadpour K, Long KZ, Hayatbakhsh R, Marks GC. Randomised comparison of the effects of Sprinkles and Foodlets with the currently recommended supplement ( Drops ) on micronutrient status and growth in Iranian children. Eur J Clin Nutr [Internet]. 2011;1287–94. Available from:

Sazawal S, Habib AKMA, Dhingra U, Dutta A, Dhingra P, Sarkar A, et al. Impact of micronutrient fortification of yoghurt on micronutrient status markers and growth – a randomized double blind controlled trial among school children in Bangladesh. BMC Public Health [Internet]. 2013;13(1):1. Available from: BMC Public Health

Toxqui L, Gonza C, Blanco-rojo R, Pe AM, Delgado MA, Vaquero MP. Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice : a randomised , double-blind , placebo-controlled study in Spanish iron-deficient women British Journal of Nutrition. 2011;1652–9.

Rawat R, Saha KK, Kennedy A, Rohner F, Ruel M, Menon P. Anaemia in infancy in rural Bangladesh : contribution of iron deficiency , infections and poor feeding practices. 2014;172–81.

Hartman-craven B, Christofides A, Connor DLO, Zlotkin S. BMC Pregnancy and Childbirth supplement compared to a traditional tablet in pregnant women. 2009;11:1–12.

Chen K, Ph D, Zhang X, Ph D, D TLM, Chen L, et al. Effect of vitamin A , vitamin A plus iron and multiple micronutrient-fortified seasoning powder on infectious morbidity of preschool children. Nutrition [Internet]. 2011;27(4):428–34. Available from:

Rohner F, Raso G, Aké-tano SOP, Tschannen AB, Mascie-taylor CGN, Northrop-clewes CA. The Effects of an Oil and Wheat Flour Fortification Program on Pre-School Children and Women of Reproductive Age Living in Côte d ’ Ivoire , a Malaria-Endemic Area. 2016;1–12.

Hund L, Northrop-clewes CA, Nazario R, Suleymanova D, Mirzoyan L, Irisova M, et al. A Novel Approach to Evaluating the Iron and Folate Status of Women of Reproductive Age in Uzbekistan after 3 Years of Flour Fortification with Micronutrients. 2013;8(11):1–12.

Trial CC, Perignon M, Fiorentino M, Kuong K, Dijkhuizen MA. Hemoglobin , Iron and Vitamin A Status of. 2016;

Banerjee A, Barnhardt S, Du E. Can iron-forti fi ed salt control anemia ? Evidence from two experiments in rural Bihar. 2018;133(June 2017):127–46.

Kuriyan R, Thankachan P, Selvam S, Pauline M, Srinivasan K, Kamath-jha S, et al. The effects of regular consumption of a multiple micronutrient forti fi ed milk beverage on the micronutrient status of school children and on their mental and physical performance. Clin Nutr [Internet]. 2016;35(1):190–8. Available from:

Banu AT, Mageswari SU. Nutritional status and effect of seaweed chocolate on anemic adolescent girls. Food Sci Hum Wellness [Internet]. 2015;4(1):28–34. Available from:

Article O. Double-blind randomized controlled trial of rolls fortified with microencapsulated iron. 2012;

Kumar MV, Rajagopalan S. Trial Using Multiple Micronutrient Food Supplement and its Effect on Cognition. 2008;75:671–8.

Stuetz W, Ilona V, Rose C, Jean S, Juergen L, Erhardt G, et al. Micronutrient status in lactating mothers before and after introduction of fortified flour : cross-sectional surveys in Maela refugee camp. 2012;425–34.

Martorell R, Ascencio M, Tacsan L, Alfaro T, Young MF, Addo OY, et al. Effectiveness evaluation of the food fortification program of Costa Rica : impact on anemia prevalence and hemoglobin concentrations in. 2015;

Magon A, Collin SM, Joshi P, Late GD, Attlee A, Mathur B. Leaf Concentrate Fortification of Antenatal Protein- Calorie Snacks Improves Pregnancy Outcomes. 2014;32(3):430–40.

Ndemwa P, Klotz CL, Mwaniki D, Sun K, Muniu E, Andango P, et al. Relationship of the availability of micronutrient powder with iron status and hemoglobin among women and children in the Kakuma Refugee Camp , Kenya. 2011;32(3):286–92.

Choudhury N, Aimone A, Hyder SMZ, Zlotkin SH. Relative efficacy of micronutrient powders versus iron – folic acid tablets in controlling anemia in women in the second trimester of pregnancy. 2012;33(2):142–50.

Luque A, La E. Comparative study of the oral absorption of microencapsulated ferric saccharate and ferrous sulfate in humans. 2014;567–74.

Rahman AS, Ahmed T, Ahmed F, Alam MS, Wahed MA, Sack DA. Original Article Double-blind cluster randomised controlled trial of wheat flour chapatti fortified with micronutrients on the status of vitamin A and iron in school-aged children in rural Bangladesh. 2015;11:120–31.

Andersson M, Theis W, Zimmermann MB, Foman JT, Ja M, Duchateau GS. Random serial sampling to evaluate efficacy of iron fortification : a randomized controlled trial of margarine fortification with ferric pyrophosphate or sodium iron edetate 1 – 3. 2010;(3):1094–104.

Goyle A, Prakash S. Efficacy of Multi-micronutrient Fortified Biscuits on Urinary Iodine Levels of Adolescent Girls from Jaipur , India. 2011;17(2):143–51.

Authors F. Nutrition & Food Science Article information : 2017;

Iannotti L, Dulience SJ, Joseph S, Cooley C, Tufte T, Cox K, et al. Fortified Snack Reduced Anemia in Rural School-Aged Children of Haiti : A Cluster-Randomized , Controlled Trial. 2016;1–14.

Pickers T, Haas JD, Rahn M, Venkatramanan S, Marquis GS, Wenger MJ, et al. Double-Fortified Salt Is Efficacious in Improving Indicators of Iron Deficiency in Female Indian. 2014;

Akkermans MD, Eussen SRBM, Horst-graat JM Van Der, Elburg RM Van, Goudoever JB Van, Brus F. A micronutrient-fortified young-child formula improves the iron and vitamin D status of healthy young European children : a randomized , double-blind controlled trial 1. 2017;25.

Meals M, Cercamondi CI, Egli IM, Mitchikpe E, Tossou F, Zeder C, et al. Total Iron Absorption by Young Women from Iron-Biofortified Pearl Millet Composite Meals Is Double That from Regular Millet Meals but Less Than That from Post-Harvest Iron-Fortified. 2013;

Haas JD, Luna S V, Lung MG, Wenger MJ, Murray-kolb LE, Beebe S, et al. Consuming Iron Biofortified Beans Increases Iron Status in Rwandan Women after 128 Days in a Randomized Controlled Feeding Trial 1 – 3. 2016;

Bahwere P, Akomo P, Mwale M, Murakami H, Banda C, Kathumba S, et al. Soya , maize , and sorghum – based ready-to-use therapeutic food with amino acid is as efficacious as the standard milk and peanut paste – based formulation for the treatment of severe acute malnutrition in children : a noninferiority individually randomi. 2017;1100–12.

Rifai R Al, Nakamura K, Seino K. Decline in the prevalence of anaemia among children of pre-school age after implementation of wheat fl our forti fi cation with multiple micronutrients in Jordan. 2015;19(8):1486–97.

Bregano W, Dichi I, Matsuo T, Miglioranza HS. Effectiveness of fortification of corn flour-derived products with hydrogen-reduced elemental iron on iron-deficiency anaemia in children and adolescents in southern Brazil. 2008;12(2):244–8.

Khan WU, Shafique S, Shikder H, Shakur YA, Sellen DW, Chowdhury JS, et al. Home fortification with calcium reduces Hb response to iron among anaemic Bangladeshi infants consuming a new multi-micronutrient powder formulation. 2013;17(7):1578–86.

Somassè YE, Dramaix M, Traoré B, Touré O, Konaté M, Diallo M, et al. The WHO recommendation of home forti fi cation of foods with multiple-micronutrient powders in children under 2 years of age and its effectiveness on anaemia and weight : a pragmatic cluster- randomized controlled trial. 2018;21(7):1350–8.

Bauserman M, Lokangaka A, Gado J, Close K, Wallace D, Kodondi K, et al. A cluster-randomized trial determining the ef fi cacy of caterpillar cereal as a locally available and sustainable complementary food to prevent stunting and anaemia. 2015;18(10):1785–92.

Abdeen Z, Ramlawi A, Qaswari R, Alrub AA, Dary O, Rambeloson Z, et al. Predicted ef fi cacy of the Palestinian wheat fl our forti fi cation programme : complementary analysis of biochemical and dietary data. 2014;18(8):1358–68.

Traore T, Ze AN, Hennart P, Donnen P. Effect of an improved local ingredient-based complementary food fortified or not with iron and selected multiple micronutrients on Hb concentration. 2010;13(11):1923–30.

Vyas S, Collin SM, Bertin E, Davys GJ, Mathur B. Leaf concentrate as an alternative to iron and folic acid supplements for anaemic adolescent girls : a randomised controlled trial in India. 2009;13(3):418–23.

Zhang X, Chen K, Qu P, Liu Y, Li T. Effect of biscuits fortified with different doses of vitamin A on indices of vitamin A status , haemoglobin and physical growth levels of pre-school children in Chongqing. 2010;13(9):1462–71.

Matias SL, Vargas-vásquez A, Pérez RB, Valdivia LA, Vivanco OA, Martín AR, et al. Effects of lipid-based nutrient supplements v . micronutrient powders on nutritional and developmental outcomes among Peruvian infants. 2017;20(16):2998–3007.

Oliveira CSM, Sampaio P, Muniz PT, Cardoso MA. Multiple micronutrients in powder delivered through primary health care reduce iron and vitamin A de fi ciencies in young Amazonian children. 2016;19(16):3039–47.

Macharia-mutie CW, Omusundi AM, Mwai JM, Mwangi AM, Brouwer ID. Simulation of the effect of maize porridge fortified with grain amaranth or micronutrient powder containing NaFeEDTA on iron intake and status in Kenyan children. 2012;16(9):1605–13.

Mclean E, Cogswell M, Egli I, Wojdyla D, Benoist B De. Worldwide prevalence of anaemia , WHO Vitamin and Mineral Nutrition Information System , 1993 – 2005. 2008;12(4):444–54.

McLean E, Cogswell M, Egli I, Wojdyla D, De Benoist B. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005. Public Health Nutr. 2009;12(4):444–54.

Mannar MGV, Hurrell RF. Food Fortification in a Globalized World. 2018. 415 p.

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